Core Business
The company's mission is to advance its novel OrthoSwitch™ technology
to (a) create rapid diagnostic tools for detection of chemical and biological targets, and (b) leverage this diagnostic platform for drug discovery applications. The OrthoSwitch platform has the demonstrated ability
to transduce molecular recognition of biological targets into a real-time (seconds) optical signal, used to identify environmental and terrorist released contaminants.

Launch
OrthoSystems, Inc. is currently in the process of adapting their OrthoSwitch sensor technology to engineer and test a Contaminant Alert System™ (CAS) for continuous water quality monitoring. This detection system will employ individual molecular switches engineered for toxins and toxic microorganisms.

Target Markets
Real-time Environmental Monitoring
Point-Of-Care Diagnostics
Drug Discovery
High Throughput Screening

Founding and Funding
OrthoSystems, Inc. was founded in March 2003 with facilities in Syracuse and Niskayuna, New York. The company has three Ph.D. scientists, a professional businessman as its president, and a support staff. The company is funded by several federal and New York State small business grants. An STTR grant from the National Institute of Health (NIH) was awarded in 2003 to develop OrthoSwitch Probes for High Throughput Screening (HTS) of anti-AIDS drug candidates. In 2004 the company was awarded an SBIR grant from the Department of Homeland Security (DHS) to engineer OrthoSwitches for rapid detection of ricin toxin. A grant from the New York Indoor Environmental Quality program will assist us in developing OrthoSwtiches for environmental contaminants in public water supplies. OrthoSystems continues to pursue funding and currently has several other grants under review. We anticipate our first sales in Q4-2004.

Facilities
OrthoSystems, Inc. is an affiliate in the CASE Incubator Center supported in part by an advanced technology grant from New York State. The company currently occupies research and office space in the Center for Science and Technology building on the Syracuse University campus. Through it's affiliation with CASE and Syracuse University, our scientists have access
to a wide variety of research services and state of the art instrumentation. These outstanding capabilities allow our R&D team to continue to advance the applications of the OrthoSwitch platform.